| http://purl.uniprot.org/citations/35552387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35552387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35552387 | http://www.w3.org/2000/01/rdf-schema#comment | "Toxins of toxin-antitoxin systems use diverse mechanisms to control bacterial growth. Here, we focus on the deleterious toxin of the atypical tripartite toxin-antitoxin-chaperone (TAC) system of Mycobacterium tuberculosis, whose inhibition requires the concerted action of the antitoxin and its dedicated SecB-like chaperone. We show that the TAC toxin is a bona fide ribonuclease and identify exact cleavage sites in mRNA targets on a transcriptome-wide scale in vivo. mRNA cleavage by the toxin occurs after the second nucleotide of the ribosomal A-site codon during translation, with a strong preference for CCA codons in vivo. Finally, we report the cryo-EM structure of the ribosome-bound TAC toxin in the presence of native M. tuberculosis cspA mRNA, revealing the specific mechanism by which the TAC toxin interacts with the ribosome and the tRNA in the P-site to cleave its mRNA target."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-30373-w"xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-30373-w"xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Genevaux P."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Genevaux P."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Redder P."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Redder P."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Gillet R."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Gillet R."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Mourey L."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Mourey L."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Guillet V."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Guillet V."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Falquet L."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Falquet L."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Mansour M."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Mansour M."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Akarsu H."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Akarsu H."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Slama N."xsd:string |
| http://purl.uniprot.org/citations/35552387 | http://purl.uniprot.org/core/author | "Slama N."xsd:string |