| http://purl.uniprot.org/citations/35559678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35559678 | http://www.w3.org/2000/01/rdf-schema#comment | "Boundaries in animal genomes delimit contact domains with enhanced internal contact frequencies and have debated functions in limiting regulatory cross-talk between domains and guiding enhancers to target promoters. Most mammalian boundaries form by stalling of chromosomal loop-extruding cohesin by CTCF, but most Drosophila boundaries form CTCF independently. However, how CTCF-independent boundaries form and function remains largely unexplored. Here, we assess genome folding and developmental gene expression in fly embryos lacking the ubiquitous boundary-associated factor Cp190. We find that sequence-specific DNA binding proteins such as CTCF and Su(Hw) directly interact with and recruit Cp190 to form most promoter-distal boundaries. Cp190 is essential for early development and prevents regulatory cross-talk between specific gene loci that pattern the embryo. Cp190 was, in contrast, dispensable for long-range enhancer-promoter communication at tested loci. Cp190 is thus currently the major player in fly boundary formation and function, revealing that diverse mechanisms evolved to partition genomes into independent regulatory domains."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.abl8834"xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Restrepo S."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Guex N."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Waridel P."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Iseli C."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Taschner M."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Cousin P."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Kaushal A."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Aiden E.L."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Gambetta M.C."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Mohana G."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Dorier J."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/author | "Semenova A."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/pages | "eabl8834"xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/title | "Essential role of Cp190 in physical and regulatory boundary formation."xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/35559678 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35559678 |
| http://purl.uniprot.org/citations/35559678 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35559678 |
| http://purl.uniprot.org/uniprot/#_A0A021WW32-mappedCitation-35559678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35559678 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6W1-mappedCitation-35559678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35559678 |