| http://purl.uniprot.org/citations/35578024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35578024 | http://www.w3.org/2000/01/rdf-schema#comment | "The CST-Polα/primase complex is essential for telomere maintenance and functions to counteract resection at double-strand breaks. We report a 4.6-Å resolution cryo-EM structure of human CST-Polα/primase, captured prior to catalysis in a recruitment state stabilized by chemical cross-linking. Our structure reveals an evolutionarily conserved interaction between the C-terminal domain of the catalytic POLA1 subunit and an N-terminal expansion in metazoan CTC1. Cross-linking mass spectrometry and negative-stain EM analysis provide insight into CST binding by the flexible POLA1 N-terminus. Finally, Coats plus syndrome disease mutations previously characterized to disrupt formation of the CST-Polα/primase complex map to protein-protein interfaces observed in the recruitment state. Together, our results shed light on the architecture and stoichiometry of the metazoan fill-in machinery."xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-022-00766-y"xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/author | "Nudler E."xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/author | "Walz T."xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/author | "de Lange T."xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/author | "Svetlov V."xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/author | "Zinder J.C."xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/author | "Cai S.W."xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/author | "Bush M.W."xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/pages | "813-819"xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/title | "Cryo-EM structure of the human CST-Polalpha/primase complex in a recruitment state."xsd:string |
| http://purl.uniprot.org/citations/35578024 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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