| http://purl.uniprot.org/citations/35579417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35579417 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis. Binding of IL-27 to cell surface receptors, IL-27Rα and gp130, results in activation of receptor-associated Janus Kinases and nuclear translocation of Signal Transducer and Activator of Transcription 1 (STAT1) and STAT3 transcription factors. Despite the emerging therapeutic importance of this cytokine axis in cancer and autoimmunity, a molecular blueprint of the IL-27 receptor signaling complex, and its relation to other gp130/IL-12 family cytokines, is currently unclear. We used cryogenic-electron microscopy to determine the quaternary structure of IL-27, composed of p28 and Epstein-Barr Virus-Induced 3 (Ebi3) subunits, bound to receptors, IL-27Rα and gp130. The resulting 3.47 Å resolution structure revealed a three-site assembly mechanism nucleated by the central p28 subunit of the cytokine. The overall topology and molecular details of this binding are reminiscent of IL-6 but distinct from related heterodimeric cytokines IL-12 and IL-23. These results indicate distinct receptor assembly mechanisms used by heterodimeric cytokines with important consequences for targeted agonism and antagonism of IL-27 signaling."xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.78463"xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/author | "Tsutsumi N."xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/author | "Jude K.M."xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/author | "Glassman C.R."xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/author | "Caveney N.A."xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/pages | "e78463"xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/title | "Structure of the IL-27 quaternary receptor signaling complex."xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/35579417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35579417 |
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