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| http://purl.uniprot.org/citations/35580499 | http://www.w3.org/2000/01/rdf-schema#comment | "Cadmium (Cd) is toxic to plants, which have evolved multiple strategies to cope with Cd stress. In this study, we identified a nucleus-localized NAC-type transcription factor, ANAC004, which is induced by Cd and involved in regulating Cd resistance in Arabidopsis. First, anac004 mutants exhibited Cd sensitive phenotype and accumulated more Cd (12-23% higher than wild type in roots and shoots); plants overexpressing ANAC004 showed the opposite phenotype and with lower Cd accumulation. Second, ANAC004 enhanced Cd fixation in cell wall hemicellulose, thus reducing Cd2+ influx into root cells. Third, ANAC004 was involved in the process of vacuolar Cd compartmentalization by regulating the genes associated with Cd detoxification (PCS1/2, NAS4, ABCC1/2/3, MTP1/3, IREG2 and NRAMP3/4). Fourth, ANAC004 reduced root-to-shoot Cd translocation through down-regulated Cd translocation-related genes (HMA2 and HMA4). Finally, the expression of genes related to ABA synthesis (AAO3, MCSU, and NCED3) and the activities of antioxidant enzymes (SOD, POD and CAT) were all reduced in anac004 mutants, leading to reduced levels of endogenous ABA and increased accumulation of reactive oxygen species (O2.- and H2O2) and MDA, which ultimately weakened resistance to Cd. Our results suggest that ANAC004 decreases Cd accumulation in Arabidopsis through enhancing cell wall Cd immobilization, increasing vacuolar Cd detoxification, and inhibiting Cd translocation, thus improving Cd resistance, processes that might be mediated by ABA signaling and antioxidant defense systems."xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jhazmat.2022.129121"xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/author | "Zhang X.L."xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/author | "Zhu X.F."xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/author | "Shen R.F."xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/author | "Meng Y.T."xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/name | "J Hazard Mater"xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/pages | "129121"xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/title | "Transcription factor ANAC004 enhances Cd tolerance in Arabidopsis thaliana by regulating cell wall fixation, translocation and vacuolar detoxification of Cd, ABA accumulation and antioxidant capacity."xsd:string |
| http://purl.uniprot.org/citations/35580499 | http://purl.uniprot.org/core/volume | "436"xsd:string |
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