| http://purl.uniprot.org/citations/35583918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35583918 | http://www.w3.org/2000/01/rdf-schema#comment | "Cells sense and integrate external information from diverse sources that include mechanical cues. Shaping of tissues during development may thus require coordination between mechanical forces from morphogenesis and cell-cell signalling to confer appropriate changes in gene expression. By live-imaging Notch-induced transcription in real time, we have discovered that morphogenetic movements during Drosophila gastrulation bring about an increase in activity-levels of a Notch-responsive enhancer. Mutations that disrupt the timing of gastrulation resulted in concomitant delays in transcription up-regulation that correlated with the start of mesoderm invagination. As a similar gastrulation-induced effect was detected when transcription was elicited by the intracellular domain NICD, it cannot be attributed to forces exerted on Notch receptor activation. A Notch-independent vnd enhancer also exhibited a modest gastrulation-induced activity increase in the same stripe of cells. Together, these observations argue that gastrulation-associated forces act on the nucleus to modulate transcription levels. This regulation was uncoupled when the complex linking the nucleoskeleton and cytoskeleton (LINC) was disrupted, indicating a likely conduit. We propose that the coupling between tissue-level mechanics, arising from gastrulation, and enhancer activity represents a general mechanism for ensuring correct tissue specification during development and that Notch-dependent enhancers are highly sensitive to this regulation."xsd:string |
| http://purl.uniprot.org/citations/35583918 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.73656"xsd:string |
| http://purl.uniprot.org/citations/35583918 | http://purl.uniprot.org/core/author | "Bray S."xsd:string |
| http://purl.uniprot.org/citations/35583918 | http://purl.uniprot.org/core/author | "Falo-Sanjuan J."xsd:string |
| http://purl.uniprot.org/citations/35583918 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35583918 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/35583918 | http://purl.uniprot.org/core/pages | "e73656"xsd:string |
| http://purl.uniprot.org/citations/35583918 | http://purl.uniprot.org/core/title | "Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation."xsd:string |
| http://purl.uniprot.org/citations/35583918 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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