| http://purl.uniprot.org/citations/35584187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35584187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35584187 | http://www.w3.org/2000/01/rdf-schema#comment | "Pseudorabies virus (PRV) has evolved various immune evasion mechanisms that target host antiviral immune responses. However, it is unclear whether and how PRV encoded proteins modulate the cGAS-STING axis for immune evasion. Here, we show that PRV tegument protein UL13 inhibits STING-mediated antiviral signaling via regulation of STING stability. Mechanistically, UL13 interacts with the CDN domain of STING and recruits the E3 ligase RING-finger protein 5 (RNF5) to promote K27-/K29-linked ubiquitination and degradation of STING. Consequently, deficiency of RNF5 enhances host antiviral immune responses triggered by PRV infection. In addition, mutant PRV lacking UL13 impaired in antagonism of STING-mediated production of type I IFNs and shows attenuated pathogenicity in mice. Our findings suggest that PRV UL13 functions as an antagonist of IFN signaling via a novel mechanism by targeting STING to persistently evade host antiviral responses."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1010544"xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1010544"xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Luan X."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Luan X."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Shang Y."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Shang Y."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Kong Z."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/author | "Kong Z."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/name | "PLoS Pathog."xsd:string |
| http://purl.uniprot.org/citations/35584187 | http://purl.uniprot.org/core/name | "PLoS Pathog."xsd:string |