| http://purl.uniprot.org/citations/35584678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35584678 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila Toll-1 and all mammalian Toll-like receptors regulate innate immunity. However, the functions of the remaining eight Toll-related proteins in Drosophila are not fully understood. Here, we show that Drosophila Toll-9 is necessary and sufficient for a special form of compensatory proliferation after apoptotic cell loss (undead apoptosis-induced proliferation [AiP]). Mechanistically, for AiP, Toll-9 interacts with Toll-1 to activate the intracellular Toll-1 pathway for nuclear translocation of the NF-κB-like transcription factor Dorsal, which induces expression of the pro-apoptotic genes reaper and hid. This activity contributes to the feedback amplification loop that operates in undead cells. Given that Toll-9 also functions in loser cells during cell competition, we define a general role of Toll-9 in cellular stress situations leading to the expression of pro-apoptotic genes that trigger apoptosis and apoptosis-induced processes such as AiP. This work identifies conceptual similarities between cell competition and AiP."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110817"xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/author | "Nie Y."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/author | "Brown E."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/author | "Ip Y.T."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/author | "Bergmann A."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/author | "Lee T.V."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/author | "Tanji T."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/author | "Amcheslavsky A."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/author | "Shields A."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/pages | "110817"xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/title | "Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/35584678 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35584678 |
| http://purl.uniprot.org/citations/35584678 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35584678 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHQ0-mappedCitation-35584678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35584678 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY4-mappedCitation-35584678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35584678 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LFI7-mappedCitation-35584678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35584678 |
| http://purl.uniprot.org/uniprot/#_E1JHD6-mappedCitation-35584678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35584678 |
| http://purl.uniprot.org/uniprot/#_E1JHK1-mappedCitation-35584678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35584678 |
| http://purl.uniprot.org/uniprot/#_E1JHK2-mappedCitation-35584678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35584678 |
| http://purl.uniprot.org/uniprot/#_P15330-mappedCitation-35584678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35584678 |