| http://purl.uniprot.org/citations/35587511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35587511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35587511 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular basis of interindividual clinical variability upon infection with Staphylococcus aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase OTULIN, encoded by a gene on chromosome 5p. Patients suffer from episodes of life-threatening necrosis, typically triggered by S. aureus infection. The disorder is phenocopied in patients with the 5p-(Cri-du-Chat) chromosomal deletion syndrome. OTULIN haploinsufficiency causes an accumulation of linear ubiquitin in dermal fibroblasts, but tumor necrosis factor receptor-mediated nuclear factor κB signaling remains intact. Blood leukocyte subsets are unaffected. The OTULIN-dependent accumulation of caveolin-1 in dermal fibroblasts, but not leukocytes, facilitates the cytotoxic damage inflicted by the staphylococcal virulence factor α-toxin. Naturally elicited antibodies against α-toxin contribute to incomplete clinical penetrance. Human OTULIN haploinsufficiency underlies life-threatening staphylococcal disease by disrupting cell-intrinsic immunity to α-toxin in nonleukocytic cells."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abm6380"xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abm6380"xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Liston A."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Liston A."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Yang R."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Yang R."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Wouters C."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Wouters C."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Boisson B."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Boisson B."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Molina H."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Molina H."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Lyonnet S."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Lyonnet S."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Casanova J.L."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Casanova J.L."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Aksentijevich I."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Aksentijevich I."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Kastner D.L."xsd:string |
| http://purl.uniprot.org/citations/35587511 | http://purl.uniprot.org/core/author | "Kastner D.L."xsd:string |