| http://purl.uniprot.org/citations/35609215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35609215 | http://www.w3.org/2000/01/rdf-schema#comment | "Polo-like-kinase (PLK) 1 activity is associated with maintaining the functional and physical properties of the centrosome's pericentriolar matrix (PCM). In this study, we use a multimodal approach of human cells (HeLa), zebrafish embryos, and phylogenic analysis to test the role of a PLK1 binding protein, cenexin, in regulating the PCM. Our studies identify that cenexin is required for tempering microtubule nucleation by maintaining PCM cohesion in a PLK1-dependent manner. PCM architecture in cenexin-depleted zebrafish embryos was rescued with wild-type human cenexin, but not with a C-terminal cenexin mutant (S796A) deficient in PLK1 binding. We propose a model where cenexin's C terminus acts in a conserved manner in eukaryotes, excluding nematodes and arthropods, to sequester PLK1 that limits PCM substrate phosphorylation events required for PCM cohesion."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e22-01-0015"xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Lan Y."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Hehnly H."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Freshour J."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Curtis E."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Bates M."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Ahmed-Braimeh Y.H."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Aljiboury A."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Cammerino T."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Magny D."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/author | "Mujcic A."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/pages | "br14"xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/title | "Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1."xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/35609215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35609215 |
| http://purl.uniprot.org/citations/35609215 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35609215 |
| http://purl.uniprot.org/uniprot/E7F186#attribution-52FD35FCFB0BF59B57C061930AE101E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/35609215 |
| http://purl.uniprot.org/uniprot/#_A0A024R8A5-mappedCitation-35609215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35609215 |
| http://purl.uniprot.org/uniprot/#_B3KSD5-mappedCitation-35609215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35609215 |
| http://purl.uniprot.org/uniprot/#_A0A8J8YVX4-mappedCitation-35609215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35609215 |
| http://purl.uniprot.org/uniprot/#_A0A8J8Z1C3-mappedCitation-35609215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35609215 |