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http://purl.uniprot.org/citations/35611665http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/35611665http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

: Epstein-Barr virus-associated gastric cancers (EBVaGCs) have unique molecular and clinicopathological characteristics. The cyclic GMP-AMP synthase-stimulator of interferon genes (STING) pathway is recently recognized as the critical innate immunity against pathogens and tumors. STING is also a master regulator in the cancer-immunity cycle and targeting STING could synergize with existing immune-checkpoint therapies. However, the role of STING in GC, especially in EBVaGC, and its correlation with programmed death-ligand 1 (PD-L1) remain largely unclear.

Methods

We collected 78 cases of EBVaGCs and 210 cases of EBV-negative GC (EBVnGC) from a total of 1,443 cases of GC analyzed by EBV-encoded small RNA in situ hybridization. We investigated STING and PD-L1 expression and their concomitant prognostic value in EBVaGCs and EBVnGCs using tissue microarray and immunohistochemistry. The effects of STING and PD-L1 expression on the overall survival of patients with EBVaGC or EBVnGC were assessed by univariate and multivariate analysis.

Results

We found that both STING and PD-L1 exhibited significantly higher expression in the EBVaGCs than that in the EBVnGCs. The expression of STING was positively correlated with that of PD-L1 in EBVaGCs. Simultaneous negative expression of STING and PD-L1, and positive expression of STING were independent prognostic risk factors for EBVaGC and EBVnGC, respectively.

Conclusions

This is the first prognostic retrospective study of STING and PD-L1 expression and the prognosis among EBVaGC and EBVnGC. The expression and prognostic value of STING and PD-L1 are different in the two types of GCs. STING and PD-L1 are promising prognostic biomarkers and therapeutic targets for EBVaGC and EBVnGC."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.org/dc/terms/identifier"doi:10.5009/gnl210359"xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Chen X."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Fan X."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Fu Y."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Li L."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Sun Q."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Xu H."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Wu H."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Zhou G."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/author"Xia H."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/name"Gut Liver"xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/pages"875-891"xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/title"Prognostic Perspectives of STING and PD-L1 Expression and Correlation with the Prognosis of Epstein-Barr Virus-Associated Gastric Cancers."xsd:string
http://purl.uniprot.org/citations/35611665http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/35611665http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/35611665
http://purl.uniprot.org/citations/35611665http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/35611665
http://purl.uniprot.org/uniprot/#_A0A2R3XZB7-mappedCitation-35611665http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35611665
http://purl.uniprot.org/uniprot/#_A0A494C0W5-mappedCitation-35611665http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35611665
http://purl.uniprot.org/uniprot/#_A0A3G1PSE3-mappedCitation-35611665http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35611665
http://purl.uniprot.org/uniprot/#_A0A3S9KRB2-mappedCitation-35611665http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35611665
http://purl.uniprot.org/uniprot/#_A0A3S9KRB7-mappedCitation-35611665http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35611665
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