| http://purl.uniprot.org/citations/35613591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35613591 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcium signaling is pivotal to the circadian clockwork in the suprachiasmatic nucleus (SCN), particularly in rhythm entrainment to environmental light-dark cycles. Here, we show that a small G-protein Gem, an endogenous inhibitor of high-voltage-activated voltage-dependent calcium channels (VDCCs), is rapidly induced by light in SCN neurons via the calcium (Ca2+)-mediated CREB/CRE transcriptional pathway. Gem attenuates light-induced calcium signaling through its interaction with VDCCs. The phase-shift magnitude of locomotor activity rhythms by light, at night, increases in Gem-deficient (Gem-/-) mice. Similarly, in SCN slices from Gem-/- mice, depolarizing stimuli induce larger phase shifts of clock gene transcription rhythms that are normalized by the application of an L-type VDCC blocker, nifedipine. Voltage-clamp recordings from SCN neurons reveal that Ca2+ currents through L-type channels increase in Gem-/- mice. Our findings suggest that transcriptionally activated Gem feeds back to suppress excessive light-evoked L-type VDCC activation, adjusting the light-induced phase-shift magnitude to an appropriate level in mammals."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110844"xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Ohmori H."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Matsuo M."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Yamaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Doi M."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Okamura H."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Nakao R."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Tominaga K."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Seo K."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Taruno A."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Mizoro Y."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/author | "Kori H."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/pages | "110844"xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/title | "A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels."xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/35613591 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35613591 |
| http://purl.uniprot.org/citations/35613591 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35613591 |
| http://purl.uniprot.org/uniprot/#_Q3TH76-mappedCitation-35613591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35613591 |
| http://purl.uniprot.org/uniprot/#_Q3U4X4-mappedCitation-35613591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35613591 |
| http://purl.uniprot.org/uniprot/#_P55041-mappedCitation-35613591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35613591 |