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| http://purl.uniprot.org/citations/35621750 | http://www.w3.org/2000/01/rdf-schema#comment | "In the present study, we observed a 58% decrease in the fecundity of Drosophila melanogaster, after treatment with the cyromazine. To further elucidate the effects of cyromazine on reproduction, we counted the number of both germline stem cells (GSCs) and cystoblasts (CBs) in the ovary of a 3-day-old adult female. The results showed a significant decrease in the number of GSCs and CBs as compared to the control group. The mode of action of cyromazine is believed to be through the ecdysone signaling pathway. To further support this postulate, we observed the expression of key genes involved in the ecdysone signaling pathway and also determined the ecdysone titer from cyromazine-treated ovaries. Results indicated a significant decrease in the expression of ecdysone signaling-related genes as compared to the control group. Furthermore, the titer of the ecdysone hormone was also markedly reduced (90%) in cyromazine-treated adult ovaries, suggesting that ecdysone signaling was directly related to the decrease in the number of GSCs and CBs. However, further studies are required to understand the mechanism by which cyromazine affects the GSCs and CBs in female adult ovaries."xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.org/dc/terms/identifier | "doi:10.3390/insects13050414"xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/author | "Zhong G."xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/author | "Khalid M.Z."xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/name | "Insects"xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/pages | "414"xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/title | "Cyromazine Effects the Reproduction of Drosophila by Decreasing the Number of Germ Cells in the Female Adult Ovary."xsd:string |
| http://purl.uniprot.org/citations/35621750 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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