| http://purl.uniprot.org/citations/35640597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35640597 | http://www.w3.org/2000/01/rdf-schema#comment | "Maternal-to-zygotic transition (MZT) is the first and key step in the control of animal development and intimately related to changes in chromatin structure and histone modifications. H2AK119ub1, an important epigenetic modification in regulating chromatin configuration and function, is primarily catalyzed by PRC1 and contributes to resistance to transcriptional reprogramming in mouse embryos. In this study, the genome-wide dynamic distribution of H2AK119ub1 during MZT in mice was investigated using chromosome immunoprecipitation and sequencing. The results indicated that H2AK119ub1 accumulated in fully grown oocytes and was enriched at the TSSs of maternal genes, but was promptly declined after meiotic resumption at genome-wide including the TSSs of early zygotic genes, by a previously unidentified mechanism. Genetic evidences indicated that ubiquitin-specific peptidase 16 (USP16) is the major deubiquitinase for H2AK119ub1 in mouse oocytes. Conditional knockout of Usp16 in oocytes did not impair their survival, growth, or meiotic maturation. However, oocytes lacking USP16 have defects when undergoing zygotic genome activation or gaining developmental competence after fertilization, potentially associated with high levels of maternal H2AK119ub1 deposition on the zygotic genomes. Taken together, H2AK119ub1 level is declined during oocyte maturation by an USP16-dependent mechanism, which ensures zygotic genome reprogramming and transcriptional activation of essential early zygotic genes."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkac468"xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Shen L."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Zhu Y.Z."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Wu Y.W."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Yu J.L."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Rong Y."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Fan H.Y."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Ji S.Y."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/author | "Sha Q.Q."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/pages | "5599-5616"xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/title | "USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation."xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/35640597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35640597 |
| http://purl.uniprot.org/citations/35640597 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35640597 |
| http://purl.uniprot.org/uniprot/#_A0A087WQQ3-mappedCitation-35640597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35640597 |
| http://purl.uniprot.org/uniprot/#_A0A087WP87-mappedCitation-35640597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35640597 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU98-mappedCitation-35640597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35640597 |
| http://purl.uniprot.org/uniprot/#_A0A1L1ST44-mappedCitation-35640597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35640597 |