| http://purl.uniprot.org/citations/35649367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35649367 | http://www.w3.org/2000/01/rdf-schema#comment | "The ATP-dependent nucleosome remodeler Mi-2/CHD4 broadly modulates chromatin landscapes to repress transcription and to maintain genome integrity. Here we use individual nucleotide resolution crosslinking and immunoprecipitation (iCLIP) to show that Drosophila Mi-2 associates with thousands of mRNA molecules in vivo. Biochemical data reveal that recombinant dMi-2 preferentially binds to G-rich RNA molecules using two intrinsically disordered regions of unclear function. Pharmacological inhibition of transcription and RNase digestion approaches establish that RNA inhibits the association of dMi-2 with chromatin. We also show that RNA inhibits dMi-2-mediated nucleosome mobilization by competing with the nucleosome substrate. Importantly, this activity is shared by CHD4, the human homolog of dMi-2, strongly suggesting that RNA-mediated regulation of remodeler activity is an evolutionary conserved mechanism. Our data support a model in which RNA serves to protect actively transcribed regions of the genome from dMi-2/CHD4-mediated establishment of repressive chromatin structures."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110895"xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Zhong Y."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "John M."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Lenz J."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Mackay J.P."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Ullah I."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Albert L."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Hartmann R."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Brehm A."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Nist A."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Stiewe T."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Gossringer M."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Rossbach O."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Vazquez O."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Chung H.R."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/author | "Tholken C."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/pages | "110895"xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/title | "RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodeling."xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/35649367 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35649367 |
| http://purl.uniprot.org/citations/35649367 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35649367 |