| http://purl.uniprot.org/citations/35649376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35649376 | http://www.w3.org/2000/01/rdf-schema#comment | "Endothelial and erythropoietic lineages arise from a common developmental progenitor. Etv2 is a master transcriptional regulator required for the development of both lineages. However, the mechanisms through which Etv2 initiates the gene-regulatory networks (GRNs) for endothelial and erythropoietic specification and how the two GRNs diverge downstream of Etv2 remain incompletely understood. Here, by analyzing a hypomorphic Etv2 mutant, we demonstrate different threshold requirements for initiation of the downstream GRNs for endothelial and erythropoietic development. We show that Etv2 functions directly in a coherent feedforward transcriptional network for vascular endothelial development, and a low level of Etv2 expression is sufficient to induce and sustain the endothelial GRN. In contrast, Etv2 induces the erythropoietic GRN indirectly via activation of Tal1, which requires a significantly higher threshold of Etv2 to initiate and sustain erythropoietic development. These results provide important mechanistic insight into the divergence of the endothelial and erythropoietic lineages."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110881"xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Pennacchio L.A."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Pollard K.S."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Thomas R."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Ikegami K."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Lizama C.O."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Black B.L."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Moskowitz I.P."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Lammerts van Bueren K."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Dickel D.E."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Sinha T."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Xu S.M."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Zovein A.C."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/author | "Zlatanova I."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/pages | "110881"xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/title | "Differential Etv2 threshold requirement for endothelial and erythropoietic development."xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/35649376 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35649376 |
| http://purl.uniprot.org/citations/35649376 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35649376 |
| http://purl.uniprot.org/uniprot/#_A0A087WPL0-mappedCitation-35649376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35649376 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWS4-mappedCitation-35649376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35649376 |