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| http://purl.uniprot.org/citations/35652253 | http://www.w3.org/2000/01/rdf-schema#comment | "A goal of modern neuroscience involves understanding how connections in the brain form and function. Such a knowledge is essential to inform how defects in the exquisite complexity of nervous system growth influence neurological disease. Studies of the nervous system in the fruit fly Drosophila melanogaster enabled the discovery of a wealth of molecular and genetic mechanisms underlying development of synapses-the specialized cell-to-cell connections that comprise the essential substrate for information flow and processing in the nervous system. For years, the major driver of knowledge was the neuromuscular junction due to its ease of examination. Analogous studies in the central nervous system lagged due to a lack of genetic accessibility of specific neuron classes, synaptic labels compatible with cell-type-specific access, and high resolution, quantitative imaging strategies. However, understanding how central synapses form remains a prerequisite to understanding brain development. In the last decade, a host of new tools and techniques extended genetic studies of synapse organization into central circuits to enhance our understanding of synapse formation, organization, and maturation. In this review, we consider the current state-of-the-field. We first discuss the tools, technologies, and strategies developed to visualize and quantify synapses in vivo in genetically identifiable neurons of the Drosophila central nervous system. Second, we explore how these tools enabled a clearer understanding of synaptic development and organization in the fly brain and the underlying molecular mechanisms of synapse formation. These studies establish the fly as a powerful in vivo genetic model that offers novel insights into neural development."xsd:string |
| http://purl.uniprot.org/citations/35652253 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/iyac078"xsd:string |
| http://purl.uniprot.org/citations/35652253 | http://purl.uniprot.org/core/author | "Mosca T.J."xsd:string |
| http://purl.uniprot.org/citations/35652253 | http://purl.uniprot.org/core/author | "Duhart J.C."xsd:string |
| http://purl.uniprot.org/citations/35652253 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35652253 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/35652253 | http://purl.uniprot.org/core/pages | "iyac078"xsd:string |
| http://purl.uniprot.org/citations/35652253 | http://purl.uniprot.org/core/title | "Genetic regulation of central synapse formation and organization in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/35652253 | http://purl.uniprot.org/core/volume | "221"xsd:string |
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