| http://purl.uniprot.org/citations/35657605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35657605 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in VPS13C cause early-onset, autosomal recessive Parkinson's disease (PD). We have established that VPS13C encodes a lipid transfer protein localized to contact sites between the ER and late endosomes/lysosomes. In the current study, we demonstrate that depleting VPS13C in HeLa cells causes an accumulation of lysosomes with an altered lipid profile, including an accumulation of di-22:6-BMP, a biomarker of the PD-associated leucine-rich repeat kinase 2 (LRRK2) G2019S mutation. In addition, the DNA-sensing cGAS-STING pathway, which was recently implicated in PD pathogenesis, is activated in these cells. This activation results from a combination of elevated mitochondrial DNA in the cytosol and a defect in the degradation of activated STING, a lysosome-dependent process. These results suggest a link between ER-lysosome lipid transfer and innate immune activation in a model human cell line and place VPS13C in pathways relevant to PD pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.202106046"xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/author | "Xu P."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/author | "Shadel G.S."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/author | "De Camilli P."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/author | "Ferguson S.M."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/author | "Hancock-Cerutti W."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/author | "Leonzino M."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/author | "Tharkeshwar A.K."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/author | "Yadavalli N."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/pages | "e202106046"xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/title | "ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling."xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://purl.uniprot.org/core/volume | "221"xsd:string |
| http://purl.uniprot.org/citations/35657605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35657605 |
| http://purl.uniprot.org/citations/35657605 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35657605 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS63-mappedCitation-35657605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35657605 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SSJ3-mappedCitation-35657605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35657605 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SUY8-mappedCitation-35657605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35657605 |
| http://purl.uniprot.org/uniprot/#_A0A2R3XZB7-mappedCitation-35657605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35657605 |
| http://purl.uniprot.org/uniprot/#_A0A494C0W5-mappedCitation-35657605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35657605 |
| http://purl.uniprot.org/uniprot/#_A0A3G1PSE3-mappedCitation-35657605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35657605 |