| http://purl.uniprot.org/citations/35676242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35676242 | http://www.w3.org/2000/01/rdf-schema#comment | "Epigenome alteration in chondrocytes correlates with osteoarthritis (OA) development. H3K27me3 demethylase UTX regulates tissue homeostasis and deterioration, while its role was not yet studied in articulating joint tissue in situ. We now uncovered that increased UTX and H3K27me3 expression in articular chondrocytes positively correlated with human knee OA. Forced UTX expression upregulated the H3K27me3 enrichment at transcription factor Sox9 promoter, inhibiting key extracellular matrix molecules collagen II, aggrecan, and glycosaminoglycan in articular chondrocytes. Utx overexpression in knee joints aggravated the signs of OA, including articular cartilage damage, synovitis, osteophyte formation, and subchondral bone loss in mice. Chondrocyte-specific Utx knockout mice developed thicker articular cartilage than wild-type mice and showed few gonarthrotic symptoms during destabilized medial meniscus- and collagenase-induced joint injury. In vitro, Utx loss changed H3K27me3-binding epigenomic landscapes, which contributed to mitochondrial activity, cellular senescence, and cartilage development. Insulin-like growth factor 2 (Igf2) and polycomb repressive complex 2 (PRC2) core components Eed and Suz12 were, among others, functional target genes of Utx. Specifically, Utx deletion promoted Tfam transcription, mitochondrial respiration, ATP production and Igf2 transcription but inhibited Eed and Suz12 expression. Igf2 blockade or forced Eed or Suz12 expression increased H3K27 trimethylation and H3K27me3 enrichment at Sox9 promoter, compromising Utx loss-induced extracellular matrix overproduction. Taken together, UTX repressed articular chondrocytic activity, accelerating cartilage loss during OA. Utx loss promoted cartilage integrity through epigenetic stimulation of mitochondrial biogenesis and Igf2 transcription. This study highlighted a novel noncanonical role of Utx, in concert with PRC2 core components, in controlling H3K27 trimethylation and articular chondrocyte anabolism and OA development."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-022-04985-5"xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/author | "Wang S.Y."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/author | "Wang F.S."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/author | "Chen Y.S."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/author | "Jahr H."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/author | "Yu C.P."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/author | "Wu R.W."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/author | "Ko J.Y."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/author | "Lian W.S."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/pages | "538"xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/title | "Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration."xsd:string |
| http://purl.uniprot.org/citations/35676242 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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