| http://purl.uniprot.org/citations/35705051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35705051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35705051 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC-E regulates NK cells by displaying MHC class Ia signal peptides (VL9) to NKG2A:CD94 receptors. MHC-E can also present sequence-diverse, lower-affinity, pathogen-derived peptides to T cell receptors (TCRs) on CD8+ T cells. To understand these affinity differences, human MHC-E (HLA-E)-VL9 versus pathogen-derived peptide structures are compared. Small-angle X-ray scatter (SAXS) measures biophysical parameters in solution, allowing comparison with crystal structures. For HLA-E-VL9, there is concordance between SAXS and crystal parameters. In contrast, HLA-E-bound pathogen-derived peptides produce larger SAXS dimensions that reduce to their crystallographic dimensions only when excess peptide is supplied. Further crystallographic analysis demonstrates three amino acids, exclusive to MHC-E, that not only position VL9 close to the α2 helix, but also allow non-VL9 peptide binding with re-configuration of a key TCR-interacting α2 region. Thus, non-VL9-bound peptides introduce an alternative peptide-binding motif and surface recognition landscape, providing a likely basis for VL9- and non-VL9-HLA-E immune discrimination."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110959"xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110959"xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Sun H."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Sun H."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Harlos K."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Harlos K."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Mohammed F."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Mohammed F."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "McMichael A.J."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "McMichael A.J."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Rambo R.P."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Rambo R.P."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Springer S."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Springer S."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Gillespie G.M."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Gillespie G.M."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Quastel M."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Quastel M."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Rozbesky D."xsd:string |
| http://purl.uniprot.org/citations/35705051 | http://purl.uniprot.org/core/author | "Rozbesky D."xsd:string |