| http://purl.uniprot.org/citations/35705057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35705057 | http://www.w3.org/2000/01/rdf-schema#comment | "Intestinal epithelial tight junction disruption is a primary contributing factor in alcohol-associated endotoxemia, systemic inflammation, and multiple organ damage. Ethanol and acetaldehyde disrupt tight junctions by elevating intracellular Ca2+. Here we identify TRPV6, a Ca2+-permeable channel, as responsible for alcohol-induced elevation of intracellular Ca2+, intestinal barrier dysfunction, and systemic inflammation. Ethanol and acetaldehyde elicit TRPV6 ionic currents in Caco-2 cells. Studies in Caco-2 cell monolayers and mouse intestinal organoids show that TRPV6 deficiency or inhibition attenuates ethanol- and acetaldehyde-induced Ca2+ influx, tight junction disruption, and barrier dysfunction. Moreover, Trpv6-/- mice are resistant to alcohol-induced intestinal barrier dysfunction. Photoaffinity labeling of 3-azibutanol identifies a histidine as a potential alcohol-binding site in TRPV6. The substitution of this histidine, and a nearby arginine, reduces ethanol-activated currents. Our findings reveal that TRPV6 is required for alcohol-induced gut barrier dysfunction and inflammation. Molecules that decrease TRPV6 function have the potential to attenuate alcohol-associated tissue injury."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.110937"xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Makowski L."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Giorgianni F."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Rao R."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Vasquez V."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Bell B."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Jaggar J.H."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Shukla P.K."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Neeli I."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Aihara E."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Montrose M.H."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Cordero-Morales J.F."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Meena A.S."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Caires R."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Radic M.Z."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Beranova S."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Fernandez-Pena C."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/author | "Chaib M."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/pages | "110937"xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/title | "TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response."xsd:string |
| http://purl.uniprot.org/citations/35705057 | http://purl.uniprot.org/core/volume | "39"xsd:string |