| http://purl.uniprot.org/citations/35709277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35709277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35709277 | http://www.w3.org/2000/01/rdf-schema#comment | "The elongation of eukaryotic selenoproteins relies on a poorly understood process of interpreting in-frame UGA stop codons as selenocysteine (Sec). We used cryo-electron microscopy to visualize Sec UGA recoding in mammals. A complex between the noncoding Sec-insertion sequence (SECIS), SECIS-binding protein 2 (SBP2), and 40S ribosomal subunit enables Sec-specific elongation factor eEFSec to deliver Sec. eEFSec and SBP2 do not interact directly but rather deploy their carboxyl-terminal domains to engage with the opposite ends of the SECIS. By using its Lys-rich and carboxyl-terminal segments, the ribosomal protein eS31 simultaneously interacts with Sec-specific transfer RNA (tRNASec) and SBP2, which further stabilizes the assembly. eEFSec is indiscriminate toward l-serine and facilitates its misincorporation at Sec UGA codons. Our results support a fundamentally distinct mechanism of Sec UGA recoding in eukaryotes from that in bacteria."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abg3875"xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abg3875"xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Simonovic M."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Simonovic M."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Burger J."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Spahn C.M.T."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Spahn C.M.T."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Buerger J."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Buerger J."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Hilal T."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Hilal T."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Loerke J."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Loerke J."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Mielke T."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Mielke T."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Copeland P.R."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Copeland P.R."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Dobosz-Bartoszek M."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Dobosz-Bartoszek M."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Grozdanovic M."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Grozdanovic M."xsd:string |
| http://purl.uniprot.org/citations/35709277 | http://purl.uniprot.org/core/author | "Killam B.Y."xsd:string |