| http://purl.uniprot.org/citations/35716086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35716086 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we investigated the role of calcium/calmodulin-dependent protein kinase II (CaMKII) in contraction-stimulated glucose uptake in skeletal muscle. C2C12 myotubes were contracted by electrical pulse stimulation (EPS), and treadmill running was used to exercise mice. The activities of CaMKII, the small G protein Rac1, and the Rac1 effector kinase PAK1 were elevated in muscle by running exercise or EPS, while they were lowered by the CaMKII inhibitor KN-93 and/or small interfering RNA (siRNA)-mediated knockdown. EPS induced the mRNA and protein expression of the Rac1-GEF Kalirin in a CaMKII-dependent manner. EPS-induced Rac1 activation was lowered by the Kalirin inhibitor ITX3 or siRNA-mediated Kalirin knockdown. KN-93, ITX3, and siRNA-mediated Kalirin knockdown reduced EPS-induced glucose uptake. These findings define a CaMKII-Kalirin-Rac1 signaling pathway that contributes to contraction-stimulated glucose uptake in skeletal muscle myotubes and tissue."xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.14428"xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/author | "Yao Z."xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/author | "Qi R."xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/author | "Niu W."xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/pages | "3159-3175"xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/title | "Kalirin mediates Rac1 activation downstream of calcium/calmodulin-dependent protein kinase II to stimulate glucose uptake during muscle contraction."xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://purl.uniprot.org/core/volume | "596"xsd:string |
| http://purl.uniprot.org/citations/35716086 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35716086 |
| http://purl.uniprot.org/citations/35716086 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35716086 |
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