| http://purl.uniprot.org/citations/35720357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35720357 | http://www.w3.org/2000/01/rdf-schema#comment | "CD5 is constitutively expressed on all T cells and is a negative regulator of lymphocyte function. However, the full extent of CD5 function in immunity remains unclear. CD5 deficiency impacts thymic selection and extra-thymic regulatory T cell generation, yet CD5 knockout was reported to cause no immune pathology. Here we show that CD5 is a key modulator of gut immunity. We generated mice with inducible CD5 knockdown (KD) in the autoimmune-prone nonobese diabetic (NOD) background. CD5 deficiency caused T cell-dependent wasting disease driven by chronic gut immune dysregulation. CD5 inhibition also exacerbated acute experimental colitis. Mechanistically, loss of CD5 increased phospho-Stat3 levels, leading to elevated IL-17A secretion. Our data reveal a new facet of CD5 function in shaping the T cell cytokine profile."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2022.906499"xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Ishikawa Y."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Schuster C."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Zheng P."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Love P.E."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Kissler S."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Hatzihristidis T."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Ruckdeschel A."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Kiaf B."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/author | "Nieves-Bonilla J."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/pages | "906499"xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/title | "CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells."xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/35720357 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35720357 |
| http://purl.uniprot.org/citations/35720357 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35720357 |
| http://purl.uniprot.org/uniprot/#_A0A494B9V0-mappedCitation-35720357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35720357 |
| http://purl.uniprot.org/uniprot/#_A0A494BB49-mappedCitation-35720357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35720357 |
| http://purl.uniprot.org/uniprot/#_P13379-mappedCitation-35720357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35720357 |
| http://purl.uniprot.org/uniprot/#_Q3UP78-mappedCitation-35720357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35720357 |
| http://purl.uniprot.org/uniprot/#_Q91X69-mappedCitation-35720357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35720357 |