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http://purl.uniprot.org/citations/35724923http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/35724923http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The aim of this review is to update data concerning the impact of HLA-C KIR system on placental disorders and assess the involvement on ART clinical outcomes.

Method

Ensuring the maintenance of human pregnancy requires the set up of immunological tolerance to prevent foetus rejection. This phenomenon involves different actors of the immune system: among them, uterine NK cells (uNK) hold specific KIR (killer-cell immunoglobulin-like) receptors linking to HLA molecules on the surface of trophoblastic cells at implantation. Many studies provided evidence that the specific interaction between maternal KIR and foetal HLA-C could influence the process of placentation; according to the KIR haplotype and the type of HLA-C, the interaction could be detrimental for placental function. We reviewed the latest data available regarding HLA-C KIR interactions and ART outcomes.

Results

The available results highlight a significant increase of preeclampsia risk and recurrent miscarriages when the maternal inhibitory haplotype KIR AA is present, this risk is all the more enhanced when the interaction occurs with foetal HLA-C2. Recent data suggest the consequences of this detrimental interaction in case of DET (double embryo transfer) or use of donor's oocytes in ART practice. On the other hand, maternal KIR AB or BB haplotypes haven't been related to an additional obstetrical risk, as well as the foetal HLA-C1 homozygous allotype.

Conclusion

Despite the existence of many confoundings in current literature on the subject, interaction between maternal KIR and foetal HLA-C represent a promising target lead to broaden the spectrum of placental defects etiologies, especially in the reproductive health area."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.org/dc/terms/identifier"doi:10.1016/j.gofs.2022.06.003"xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/author"Brouillet S."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/author"Barry F."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/author"Robert L."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/author"Hamamah S."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/author"Anahory T."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/author"Gala A."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/author"Ferrieres-Hoa A."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/author"Benart L."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/author"Loup V."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/name"Gynecol Obstet Fertil Senol"xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/pages"600-609"xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/title"[HLA-C KIR interactions and placental defects: Implications in ART pregnancy issues]."xsd:string
http://purl.uniprot.org/citations/35724923http://purl.uniprot.org/core/volume"50"xsd:string
http://purl.uniprot.org/citations/35724923http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/35724923
http://purl.uniprot.org/citations/35724923http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/35724923
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http://purl.uniprot.org/uniprot/#_A0A089N0V0-mappedCitation-35724923http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35724923
http://purl.uniprot.org/uniprot/#_A0A0A7C850-mappedCitation-35724923http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35724923
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http://purl.uniprot.org/uniprot/#_A0A0A7C8P4-mappedCitation-35724923http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35724923
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