| http://purl.uniprot.org/citations/35727300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35727300 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThe fasciculus retroflexus is the prominent efferent pathway from the habenular complex. Medial habenular axons form a core packet whereas lateral habenular axons course in a surrounding shell. Both groups of fibers share the same initial pathway but differ in the final segment of the tract, supposedly regulated by surface molecules. The gene Amigo2 codes for a membrane adhesion molecule with an immunoglobulin-like domain 2 and is selectively expressed in the medial habenula. We present it as a candidate for controlling the fasciculation behavior of medial habenula axons.ResultsFirst, we studied the development of the habenular efferents in an Amigo2 lack of function mouse model. The fasciculus retroflexus showed a variable defasciculation phenotype. Gain of function experiments allowed us to generate a more condensed tract and rescued the Amigo2 knock-out phenotype. Changes in Amigo2 function did not alter the course of habenular fibers.ConclusionWe have demonstrated that Amigo2 plays a subtle role in the fasciculation of the fasciculus retroflexus."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.513"xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/author | "Martinez S."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/author | "Puelles E."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/author | "Echevarria D."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/author | "Andreu-Cervera A."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/author | "Almagro-Garcia F."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/author | "Company V."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/author | "Murcia-Ramon R."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/author | "Aracil-Pastor P."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/pages | "1834-1847"xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/title | "Adhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexus."xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://purl.uniprot.org/core/volume | "251"xsd:string |
| http://purl.uniprot.org/citations/35727300 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35727300 |
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