| http://purl.uniprot.org/citations/35729260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35729260 | http://www.w3.org/2000/01/rdf-schema#comment | "Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) might be involved in the activation of important pathways related to tumor immune escape, along with programmed death-ligand 1 (PD-L1). Here, we aimed to investigate the correlation between the expression of Siglec-15 and PD-L1 in nasopharyngeal carcinoma (NPC) patients. We determined the expression of PD-L1 via immunohistochemical staining and that of Siglec-15 via immunofluorescence staining in 182 NPC tissue samples. A significant correlation was identified between the PD-L1 and Siglec-15 expression (P = 0.000). Moreover, Kaplan-Meier survival curves showed that PD-L1 expression was associated with improved overall survival (OS) (P = 0.025) and Siglec-15 expression was associated with improved distant failure-free survival (D-FFS) (P = 0.048). Moreover, multivariate Cox analysis showed that PD-L1 and Siglec-15 were independent predictors of OS (P = 0.020) and D-FFS (P = 0.047), respectively. The results of the log-rank test and Cox regression analyses showed that patients exhibiting no PD-L1/Siglec-15 expression had significant advantages regarding OS, compared to other groups (P = 0.037). PD-L1 and Siglec-15 may represent novel biomarkers for predicting the prognosis of NPC patients. Siglec-15 may be considered as a potential target for the development of therapeutics for NPC treatment in the future."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-022-13997-2"xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Hu H."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Xiong K."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Cui Y."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Wei M."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/author | "Yang H.'"xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/pages | "10401"xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/title | "Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma."xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/35729260 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35729260 |
| http://purl.uniprot.org/citations/35729260 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35729260 |
| http://purl.uniprot.org/uniprot/#_A7E1W7-mappedCitation-35729260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35729260 |
| http://purl.uniprot.org/uniprot/#_Q0GN75-mappedCitation-35729260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35729260 |