| http://purl.uniprot.org/citations/35732631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35732631 | http://www.w3.org/2000/01/rdf-schema#comment | "As a main regulator of cellular responses to hypoxia, the protein stability of hypoxia-inducible factor (HIF)-1α is strictly controlled by oxygen tension dependent of PHDs-catalyzed protein hydroxylation and pVHL complex-mediated proteasomal degradation. Whether HIF-1α protein stability as well as its activity can be further regulated under hypoxia is not well understood. In this study, we found that OTUB1 augments hypoxia signaling independent of PHDs/VHL and FIH. OTUB1 binds to HIF-1α and depletion of OTUB1 reduces endogenous HIF-1α protein under hypoxia. In addition, OTUB1 inhibits K48-linked polyubiquitination of HIF-1α via its non-canonical inhibition of ubiquitination activity. Furthermore, OTUB1 promotes hypoxia-induced glycolytic reprogramming for cellular metabolic adaptation. These findings define a novel regulation of HIF-1α under hypoxia and demonstrate that OTUB1-mediated HIF-1α stabilization positively regulates HIF-1α transcriptional activity and benefits cellular hypoxia adaptation."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-022-05008-z"xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Cai X."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Jia S."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Deng H."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Xiao W."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Rong F."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/author | "Ouyang G."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/pages | "560"xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/title | "OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1alpha during hypoxia adaptation."xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/35732631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35732631 |
| http://purl.uniprot.org/citations/35732631 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35732631 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-35732631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35732631 |
| http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-35732631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35732631 |