| http://purl.uniprot.org/citations/35748872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35748872 | http://www.w3.org/2000/01/rdf-schema#comment | "Topoisomerase 3β (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover and translation as did TDRD3-KO, while FMRP-KO resulted in rather distinct effects, indicating that TOP3B had stronger coordination with TDRD3 than FMRP in mRNA regulation. Second, we identified TOP3B-bound mRNAs in HCT116 cells; we found that while TOP3B did not directly influence the stability or translation of most TOP3B target mRNAs, it stabilized a subset of target mRNAs but had a more complex effect on translation-enhancing for some mRNAs whereas reducing for others. Interestingly, a point mutation that specifically disrupted TOP3B catalytic activity only partially recapitulated the effects of TOP3B-KO on mRNA stability and translation, suggesting that the impact of TOP3B on target mRNAs is partly linked to its ability to change topology of mRNAs. Collectively, our data suggest that TOP3B-TDRD3 can regulate mRNA translation and turnover by mechanisms that are dependent and independent of topoisomerase activity."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkac538"xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Shen W."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Xu D."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Xue Y."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Sen P."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Lee S.K."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Zhao K."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Su S."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "De S."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Gorospe M."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Martindale J.L."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Sharov A."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/author | "Ku W.L."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/pages | "7013-7033"xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/title | "A dual-activity topoisomerase complex regulates mRNA translation and turnover."xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/35748872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35748872 |
| http://purl.uniprot.org/citations/35748872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35748872 |