| http://purl.uniprot.org/citations/35790763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35790763 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA methylation is an evolutionarily conserved epigenetic mechanism essential for transposon silencing and heterochromatin assembly. In plants, DNA methylation widely occurs in the CG, CHG, and CHH (H = A, C, or T) contexts, with the maintenance of CHG methylation mediated by CMT3 chromomethylase. However, how CMT3 interacts with the chromatin environment for faithful maintenance of CHG methylation is unclear. Here we report structure-function characterization of the H3K9me2-directed maintenance of CHG methylation by CMT3 and its Zea mays ortholog ZMET2. Base-specific interactions and DNA deformation coordinately underpin the substrate specificity of CMT3 and ZMET2, while a bivalent readout of H3K9me2 and H3K18 allosterically stimulates substrate binding. Disruption of the interaction with DNA or H3K9me2/H3K18 led to loss of CMT3/ZMET2 activity in vitro and impairment of genome-wide CHG methylation in vivo. Together, our study uncovers how the intricate interplay of CMT3, repressive histone marks, and DNA sequence mediates heterochromatic CHG methylation."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-31627-3"xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/author | "Fang J."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/author | "Zhong X."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/author | "Biswal M."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/author | "Khudaverdyan N."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/author | "Leichter S.M."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/pages | "3877"xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/title | "Mechanistic basis for maintenance of CHG DNA methylation in plants."xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/35790763 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35790763 |
| http://purl.uniprot.org/citations/35790763 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35790763 |
| http://purl.uniprot.org/uniprot/#_P69246-mappedCitation-35790763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35790763 |
| http://purl.uniprot.org/uniprot/#_Q9AXT8-mappedCitation-35790763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35790763 |
| http://purl.uniprot.org/uniprot/P69246 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35790763 |
| http://purl.uniprot.org/uniprot/Q9AXT8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35790763 |