| http://purl.uniprot.org/citations/35803939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35803939 | http://www.w3.org/2000/01/rdf-schema#comment | "Satellite cells are required for the growth, maintenance, and regeneration of skeletal muscle. Quiescent satellite cells possess a primary cilium, a structure that regulates the processing of the GLI family of transcription factors. Here we find that GLI3 processing by the primary cilium plays a critical role for satellite cell function. GLI3 is required to maintain satellite cells in a G0 dormant state. Strikingly, satellite cells lacking GLI3 enter the GAlert state in the absence of injury. Furthermore, GLI3 depletion stimulates expansion of the stem cell pool. As a result, satellite cells lacking GLI3 display rapid cell-cycle entry, increased proliferation and augmented self-renewal, and markedly enhanced regenerative capacity. At the molecular level, we establish that the loss of GLI3 induces mTORC1 signaling activation. Therefore, our results provide a mechanism by which GLI3 controls mTORC1 signaling, consequently regulating muscle stem cell activation and fate."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-31695-5"xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/author | "Hall D."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/author | "Rudnicki M.A."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/author | "Le Grand F."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/author | "Lin A.Y.T."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/author | "Sincennes M.C."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/author | "Brun C.E."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/author | "Feige P."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/author | "Jarassier W."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/pages | "3961"xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/title | "GLI3 regulates muscle stem cell entry into GAlert and self-renewal."xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/35803939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35803939 |
| http://purl.uniprot.org/citations/35803939 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35803939 |
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| http://purl.uniprot.org/uniprot/#_P47239-mappedCitation-35803939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35803939 |
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