| http://purl.uniprot.org/citations/35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35806241 | http://www.w3.org/2000/01/rdf-schema#comment | "Copper (Cu) is one of the most indispensable micronutrients, and proper Cu homeostasis is required for plants to maintain essential cellular functions. Plants activate the Cu uptake system during Cu limitation. Although SPL7 (SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 7) and CITF1 (Cu-DEFICIENCY INDUCED TRANSCRIPTION FACTOR 1) are two transcription factors in Cu homeostasis, it remains unclear how SPL7 and CITF1 control the Cu uptake system. Here, we reveal that overexpression of CITF1 causes the enhanced tolerance to Cu deficiency and the elevated expression of Cu uptake genes COPT2, FRO4 and FRO5. Electrophoretic mobility shift assays (EMSA) and transient expression assays indicate that SPL7 directly binds to and activates the promoter of CITF1. The overexpression of CITF1 partially rescues the sensitivity of spl7-1 to Cu deficiency. Transcriptome data suggest that SPL7 and CITF1 coregulate the Cu-homeostasis-signaling network, and CITF1 has its own independent functions. Moreover, both SPL7 and CITF1 can directly bind to and activate the promoters of three Cu uptake genes COPT2, FRO4 and FRO5. This work shows the functions of CITF1 in the Cu-homeostasis-signaling network, providing insights into the complicated molecular mechanism underlying Cu homeostasis."xsd:string |
| http://purl.uniprot.org/citations/35806241 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms23137239"xsd:string |
| http://purl.uniprot.org/citations/35806241 | http://purl.uniprot.org/core/author | "Cai Y."xsd:string |
| http://purl.uniprot.org/citations/35806241 | http://purl.uniprot.org/core/author | "Liang G."xsd:string |
| http://purl.uniprot.org/citations/35806241 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35806241 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/35806241 | http://purl.uniprot.org/core/pages | "7239"xsd:string |
| http://purl.uniprot.org/citations/35806241 | http://purl.uniprot.org/core/title | "CITF1 Functions Downstream of SPL7 to Specifically Regulate Cu Uptake in Arabidopsis."xsd:string |
| http://purl.uniprot.org/citations/35806241 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/35806241 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35806241 |
| http://purl.uniprot.org/citations/35806241 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35806241 |
| http://purl.uniprot.org/uniprot/#_F4JZI4-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_A0A178UNE5-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_A0A1P8AVG1-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_A0A1P8AVI2-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_A0A1P8AVK0-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_A0A1P8B9Z4-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_F4I8F9-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_Q8S9G8-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_Q9FLW2-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_Q9STG2-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/#_Q8W110-mappedCitation-35806241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/A0A1P8B9Z4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35806241 |
| http://purl.uniprot.org/uniprot/Q9FLW2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35806241 |