| http://purl.uniprot.org/citations/35831318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35831318 | http://www.w3.org/2000/01/rdf-schema#comment | "Developmental etiologies causing complex congenital aortic root abnormalities are unknown. Here we show that deletion of Sox17 in aortic root endothelium in mice causes underdeveloped aortic root leading to a bicuspid aortic valve due to the absence of non-coronary leaflet and mispositioned left coronary ostium. The respective defects are associated with reduced proliferation of non-coronary leaflet mesenchyme and aortic root smooth muscle derived from the second heart field cardiomyocytes. Mechanistically, SOX17 occupies a Pdgfb transcriptional enhancer to promote its transcription and Sox17 deletion inhibits the endothelial Pdgfb transcription and PDGFB growth signaling to the non-coronary leaflet mesenchyme. Restoration of PDGFB in aortic root endothelium rescues the non-coronary leaflet and left coronary ostium defects in Sox17 nulls. These data support a SOX17-PDGFB axis underlying aortic root development that is critical for aortic valve and coronary ostium patterning, thereby informing a potential shared disease mechanism for concurrent anomalous aortic valve and coronary arteries."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-31815-1"xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Feng X."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Yuan X."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Zhou B."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Wu B."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Zheng D."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Lu P."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Lenz J."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Cheng W."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Chang C.P."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Sugi Y."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Esmaily M."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Butcher J.T."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Atteya M.M."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Ferro H."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/author | "Rydquist G."xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/pages | "4065"xsd:string |
| http://purl.uniprot.org/citations/35831318 | http://purl.uniprot.org/core/title | "A SOX17-PDGFB signaling axis regulates aortic root development."xsd:string |