| http://purl.uniprot.org/citations/35832006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35832006 | http://www.w3.org/2000/01/rdf-schema#comment | "In Arabidopsis, copper (Cu) transport to the ethylene receptor ETR1 mediated using RAN1, a Cu transporter located at the endoplasmic reticulum (ER), and Cu homeostasis mediated using SPL7, the key Cu-responsive transcription factor, are two deeply conserved vital processes. However, whether and how the two processes interact to regulate plant development remain elusive. We found that its C-terminal transmembrane domain (TMD) anchors SPL7 to the ER, resulting in dual compartmentalisation of the transcription factor. Immunoprecipitation coupled mass spectrometry, yeast-two-hybrid assay, luciferase complementation imaging and subcellular co-localisation analyses indicate that SPL7 interacts with RAN1 at the ER via the TMD. Genetic analysis revealed that the ethylene-induced triple response was significantly compromised in the spl7 mutant, a phenotype rescuable by RAN1 overexpression but not by SPL7 without the TMD. The genetic interaction was corroborated by molecular analysis showing that SPL7 modulates RAN1 abundance in a TMD-dependent manner. Moreover, SPL7 is feedback regulated by ethylene signalling via EIN3, which binds the SPL7 promoter and represses its transcription. These results demonstrate that ER-anchored SPL7 constitutes a cellular mechanism to regulate RAN1 in ethylene signalling and lay the foundation for investigating how Cu homeostasis conditions ethylene sensitivity in the developmental context."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.org/dc/terms/identifier | "doi:10.1111/nph.18376"xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/author | "Du J."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/author | "Cai H."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/author | "Hao C."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/name | "New Phytol"xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/pages | "878-892"xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/title | "The carboxy terminal transmembrane domain of SPL7 mediates interaction with RAN1 at the endoplasmic reticulum to regulate ethylene signalling in Arabidopsis."xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://purl.uniprot.org/core/volume | "236"xsd:string |
| http://purl.uniprot.org/citations/35832006 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35832006 |
| http://purl.uniprot.org/citations/35832006 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35832006 |
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| http://purl.uniprot.org/uniprot/#_O24606-mappedCitation-35832006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35832006 |
| http://purl.uniprot.org/uniprot/#_P49333-mappedCitation-35832006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35832006 |
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| http://purl.uniprot.org/uniprot/#_Q8S9G8-mappedCitation-35832006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35832006 |
| http://purl.uniprot.org/uniprot/Q9S7J8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35832006 |