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http://purl.uniprot.org/citations/35840466http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/35840466http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Previous studies have measured selenium levels and glutathione peroxidase 3 (GPX3) activity in patients with thalassemia major (TM). However, Selenoprotein P (SEPP), which is responsible for the storage and transport of selenium, has not been studied in thalassemia patients. This study aims to correlate thyroid functions of TM patients with their SEPP and GPX3 levels.

Materials and methods

Eighty subjects (40 controls, 40 TM patients) were included in this study. GPX3 and SEPP concentrations were measured in all subjects using sandwich ELISA. Iron, ferritin, urinary iodine, thyroxine (T4), triiodothyronine (T3), thyrotropin (TSH), anti-thyroid peroxidase (anti-TPO), and anti-human thyroglobulin (anti-hTG) concentrations were also measured.

Results

Mean SEPP concentration was higher in the TM group compared to the control group. A slight elevation in GPX3 levels was also observed in thalassemia patients, yet it was not statistically significant. In both TM patients and controls, ferritin was inversely correlated with free T4 concentration and GPX3 was inversely correlated with free T4 and T3 concentrations. There was also a negative correlation between SEPP and TSH concentrations in healthy subjects.

Conclusion

This is the first study, which has measured SEPP concentrations in thalassemia patients. SEPP levels were higher in TM patients compared to controls. Correlations between thyroid hormones and selenoproteins may indicate that selenium is necessary for thyroid function. Detailed studies are required to elaborate the role of SEPP in thyroid metabolism in thalassemia patients."xsd:string
http://purl.uniprot.org/citations/35840466http://purl.org/dc/terms/identifier"doi:10.1016/j.arcmed.2022.07.001"xsd:string
http://purl.uniprot.org/citations/35840466http://purl.uniprot.org/core/author"Parlak M."xsd:string
http://purl.uniprot.org/citations/35840466http://purl.uniprot.org/core/author"Ozturk Z."xsd:string
http://purl.uniprot.org/citations/35840466http://purl.uniprot.org/core/author"Kupesiz A."xsd:string
http://purl.uniprot.org/citations/35840466http://purl.uniprot.org/core/author"Talibova G."xsd:string
http://purl.uniprot.org/citations/35840466http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/35840466http://purl.uniprot.org/core/name"Arch Med Res"xsd:string
http://purl.uniprot.org/citations/35840466http://purl.uniprot.org/core/pages"508-515"xsd:string
http://purl.uniprot.org/citations/35840466http://purl.uniprot.org/core/title"Elevated Selenoprotein P Levels in Thalassemia Major Patients."xsd:string
http://purl.uniprot.org/citations/35840466http://purl.uniprot.org/core/volume"53"xsd:string
http://purl.uniprot.org/citations/35840466http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/35840466
http://purl.uniprot.org/citations/35840466http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/35840466
http://purl.uniprot.org/uniprot/#_P49908-mappedCitation-35840466http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35840466
http://purl.uniprot.org/uniprot/P49908http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/35840466