| http://purl.uniprot.org/citations/35841889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35841889 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen (HLA) alleles have been linked to HIV disease progression and attributed to differences in cytotoxic T lymphocyte (CTL) epitope representation. These findings are largely based on treatment-naive individuals of European and African ancestry. We assessed HLA associations with HIV-1 outcomes in 1,318 individuals from Thailand and found HLA-B∗46:01 (B∗46) associated with accelerated disease in three independent cohorts. B∗46 had no detectable effect on HIV-specific T cell responses, but this allele is unusual in containing an HLA-C epitope that binds inhibitory receptors on natural killer (NK) cells. Unbiased transcriptomic screens showed increased NK cell activation in people with HIV, without B∗46, and simultaneous single-cell profiling of surface proteins and transcriptomes revealed a NK cell subset primed for increased responses in the absence of B∗46. These findings support a role for NK cells in HIV pathogenesis, revealed by the unique properties of the B∗46 allele common only in Asia."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2022.06.005"xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Thomas R."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "O'Connell R.J."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Li S.S."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "de Souza M."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Clifford R.J."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Robb M.L."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Ehrenberg P.K."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Michael N.L."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Apps R."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Geretz A."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Butler L."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Eller L.A."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Kundu G."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Ananworanich J."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Kroon E."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Phanuphak N."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Pinyakorn S."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Sacdalan C."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Gilbert P.B."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Vasan S."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Creegan M."xsd:string |
| http://purl.uniprot.org/citations/35841889 | http://purl.uniprot.org/core/author | "Holtz T.H."xsd:string |