| http://purl.uniprot.org/citations/35851540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35851540 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon recognition of aberrantly located DNA, the innate immune sensor cyclic GMP-AMP synthase (cGAS) activates stimulator of IFN genes (STING)/IFN regulatory factor (IRF)3-driven antiviral responses. In this study, we characterized the ability of a specific variant of the human cGAS-encoding gene MB21D1, rs610913, to alter cGAS-mediated DNA sensing and viral infection. rs610913 is a frequent G>T polymorphism resulting in a P261H exchange in the cGAS protein. Data from the International Collaboration for the Genomics of HIV suggested that rs610913 nominally associates with HIV-1 acquisition in vivo. Molecular modeling of cGAS(P261H) hinted toward the possibility for an additional binding site for a potential cellular cofactor in cGAS dimers. However, cGAS(wild-type [WT]) or cGAS(P261H)-reconstituted THP-1 cGAS knockout cells shared steady-state expression of IFN-stimulated genes, as opposed to cells expressing the enzymatically inactive cGAS(G212A/S213A). Accordingly, cGAS(WT) and cGAS(P261H) cells were less susceptible to lentiviral transduction and infection with HIV-1, HSV-1, and Chikungunya virus as compared with cGAS knockout or cGAS(G212A/S213A) cells. Upon DNA challenge, innate immune activation appeared to be mildly reduced upon expression of cGAS(P261H) compared with cGAS(WT). Finally, DNA challenge of PBMCs from donors homozygously expressing rs610913 provoked a trend toward a slightly reduced type I IFN response as compared with PBMCs from GG donors. Taken together, the steady-state activity of cGAS maintains a baseline antiviral state rendering cells more refractory to IFN-stimulated gene-sensitive viral infections. rs610913 failed to grossly differ phenotypically from the WT gene, suggesting that cGAS(P261H) and WT cGAS share a similar ability to sense viral infections in vivo."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.2100685"xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Dohner K."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Sodeik B."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Fedorov R."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Jansen J."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Goffinet C."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Weber A.N.R."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Fellay J."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Thorball C.W."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Pott F."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Ducroux A."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Kazmierski J."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Loffler M.W."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Elsner C."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/author | "Zeymer O."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/pages | "535-547"xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/title | "A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913."xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://purl.uniprot.org/core/volume | "209"xsd:string |
| http://purl.uniprot.org/citations/35851540 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35851540 |