Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/35852358http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/35852358http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To correlate inflammatory cytokines and vascular endothelial growth factor (VEGF) in vitreous and plasma with vitreous retinol binding protein 3 (RBP3), diabetic retinopathy (DR) severity, and DR worsening in a population with type 1 and type 2 diabetes.

Research design and methods

RBP3, VEGF, and inflammatory cytokines were measured in plasma and vitreous samples (n = 205) from subjects of the Joslin Medalist Study and Beetham Eye Institute.

Results

Higher vitreous RBP3 concentrations were associated with less severe DR (P < 0.0001) and a reduced risk of developing proliferative DR (PDR) (P < 0.0001). Higher RBP3 correlated with increased photoreceptor segment thickness and lower vitreous interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α), and TNF-β (P < 0.05). PDR was associated with lower vitreous interferon-γ and IL-10 and higher VEGF, IL-6, and IL-15 (P < 0.05), but was not associated with their plasma concentrations.

Conclusions

Higher vitreous RBP3 concentrations are associated with less severe DR and slower rates of progression to PDR, supporting its potential as a biomarker and therapeutic agent for preventing DR worsening, possibly by lowering retinal VEGF and inflammatory cytokines."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.org/dc/terms/identifier"doi:10.2337/dc22-0165"xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Park H."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Park K."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Gautier J."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Sun J.K."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Aiello L.P."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"King G.L."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Wu I.H."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Zaitsu Y."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Fickweiler W."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Boumenna T."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Cavallerano J."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Chokshi T."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/author"Mitzner M.G."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/name"Diabetes Care"xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/pages"2159-2162"xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/title"Elevated Retinol Binding Protein 3 Concentrations Are Associated With Decreased Vitreous Inflammatory Cytokines, VEGF, and Progression of Diabetic Retinopathy."xsd:string
http://purl.uniprot.org/citations/35852358http://purl.uniprot.org/core/volume"45"xsd:string
http://purl.uniprot.org/citations/35852358http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/35852358
http://purl.uniprot.org/citations/35852358http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/35852358
http://purl.uniprot.org/uniprot/#_A2A2V4-mappedCitation-35852358http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35852358
http://purl.uniprot.org/uniprot/#_A0A0Y0IMM4-mappedCitation-35852358http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/35852358
▶