| http://purl.uniprot.org/citations/35856391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35856391 | http://www.w3.org/2000/01/rdf-schema#comment | "The P-TEFb complex promotes transcription elongation by releasing paused RNA polymerase II. P-TEFb itself is known to be inactivated through binding to the non-coding RNA 7SK but there is only limited information about mechanisms regulating their association. Here, we show that cells deficient in the RNA-binding protein hnRNP R, a known 7SK interactor, exhibit increased transcription due to phosphorylation of RNA polymerase II. Intriguingly, loss of hnRNP R promotes the release of P-TEFb from 7SK, accompanied by enhanced hnRNP A1 binding to 7SK. Additionally, we found that hnRNP R interacts with BRD4, and that hnRNP R depletion increases BRD4 binding to the P-TEFb component CDK9. Finally, CDK9 is stabilized upon loss of hnRNP R and its association with Cyclin K is enhanced. Together, our results indicate that hnRNP R negatively regulates transcription by modulating the activity and stability of the P-TEFb complex, exemplifying the multimodal regulation of P-TEFb by an RNA-binding protein."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.202255432"xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/author | "Fischer U."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/author | "Schneider C."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/author | "Bischler T."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/author | "Ji C."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/author | "Deng C."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/author | "Sendtner M."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/author | "Briese M."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/author | "Antor K."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/pages | "e55432"xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/title | "hnRNP R negatively regulates transcription by modulating the association of P-TEFb with 7SK and BRD4."xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/35856391 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35856391 |
| http://purl.uniprot.org/citations/35856391 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35856391 |
| http://purl.uniprot.org/uniprot/#_B2R7W4-mappedCitation-35856391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35856391 |
| http://purl.uniprot.org/uniprot/#_B4DMB1-mappedCitation-35856391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35856391 |
| http://purl.uniprot.org/uniprot/#_B4DMD1-mappedCitation-35856391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35856391 |
| http://purl.uniprot.org/uniprot/#_B4DT28-mappedCitation-35856391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35856391 |
| http://purl.uniprot.org/uniprot/#_O43390-mappedCitation-35856391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35856391 |
| http://purl.uniprot.org/uniprot/#_Q0VGD6-mappedCitation-35856391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35856391 |
| http://purl.uniprot.org/uniprot/#_Q6MZS5-mappedCitation-35856391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35856391 |