| http://purl.uniprot.org/citations/35857439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35857439 | http://www.w3.org/2000/01/rdf-schema#comment | "The potential for future coronavirus outbreaks highlights the need to broadly target this group of pathogens. We used an epitope-agnostic approach to identify six monoclonal antibodies that bind to spike proteins from all seven human-infecting coronaviruses. All six antibodies target the conserved fusion peptide region adjacent to the S2' cleavage site. COV44-62 and COV44-79 broadly neutralize alpha- and betacoronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants BA.2 and BA.4/5, albeit with lower potency than receptor binding domain-specific antibodies. In crystal structures of COV44-62 and COV44-79 antigen-binding fragments with the SARS-CoV-2 fusion peptide, the fusion peptide epitope adopts a helical structure and includes the arginine residue at the S2' cleavage site. COV44-79 limited disease caused by SARS-CoV-2 in a Syrian hamster model. These findings highlight the fusion peptide as a candidate epitope for next-generation coronavirus vaccine development."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abq3773"xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Hu Z."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Cong Y."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Peng L."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Tan J."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Zhao M."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Yuan M."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Leung K."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Eaton B."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Lin T.H."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Perry D."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Mascola J.R."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Nemazee D."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Crompton P.D."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Davidson E."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Yewdell J.W."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Dixit S."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Holbrook M.R."xsd:string |
| http://purl.uniprot.org/citations/35857439 | http://purl.uniprot.org/core/author | "Schmaljohn C."xsd:string |