| http://purl.uniprot.org/citations/35857630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35857630 | http://www.w3.org/2000/01/rdf-schema#comment | "The E3 ubiquitin ligase RNF12 plays essential roles during development, and the gene encoding it, RLIM, is mutated in the X-linked human developmental disorder Tonne-Kalscheuer syndrome (TOKAS). Substrates of RNF12 include transcriptional regulators such as the pluripotency-associated transcriptional repressor REX1. Using global quantitative proteomics in male mouse embryonic stem cells, we identified the deubiquitylase USP26 as a putative downstream target of RNF12 activity. RNF12 relieved REX1-mediated repression of Usp26, leading to an increase in USP26 abundance and the formation of RNF12-USP26 complexes. Interaction with USP26 prevented RNF12 autoubiquitylation and proteasomal degradation, thereby establishing a transcriptional feed-forward loop that amplified RNF12-dependent derepression of REX1 targets. We showed that the RNF12-USP26 axis operated specifically in mouse testes and was required for the expression of gametogenesis genes and for germ cell differentiation in vitro. Furthermore, this RNF12-USP26 axis was disrupted by RLIM and USP26 variants found in TOKAS and infertility patients, respectively. This work reveals synergy within the ubiquitylation cycle that controls a key developmental process in gametogenesis and that is disrupted in human genetic disorders."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.abm5995"xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Toth R."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Bach I."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Macartney T."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Bustos F."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Nardocci G."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Findlay G.M."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Segarra-Fas A."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/author | "Espejo-Serrano C."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/pages | "eabm5995"xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/title | "An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations."xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/35857630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35857630 |
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| http://purl.uniprot.org/uniprot/#_Q495F8-mappedCitation-35857630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35857630 |
| http://purl.uniprot.org/uniprot/#_Q9BXU7-mappedCitation-35857630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35857630 |