| http://purl.uniprot.org/citations/35857845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35857845 | http://www.w3.org/2000/01/rdf-schema#comment | "The motor protein myosin-15 is necessary for the development and maintenance of mechanosensory stereocilia, and mutations in myosin-15 cause hereditary deafness. In addition to transporting actin regulatory machinery to stereocilia tips, myosin-15 directly nucleates actin filament ("F-actin") assembly, which is disrupted by a progressive hearing loss mutation (p.D1647G, "jordan"). Here, we present cryo-electron microscopy structures of myosin-15 bound to F-actin, providing a framework for interpreting the impacts of deafness mutations on motor activity and actin nucleation. Rigor myosin-15 evokes conformational changes in F-actin yet maintains flexibility in actin's D-loop, which mediates inter-subunit contacts, while the jordan mutant locks the D-loop in a single conformation. Adenosine diphosphate-bound myosin-15 also locks the D-loop, which correspondingly blunts actin-polymerization stimulation. We propose myosin-15 enhances polymerization by bridging actin protomers, regulating nucleation efficiency by modulating actin's structural plasticity in a myosin nucleotide state-dependent manner. This tunable regulation of actin polymerization could be harnessed to precisely control stereocilium height."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.abl4733"xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Jiang F."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Bird J.E."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Reynolds M.J."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Bowl M.R."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Gong R."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Alushin G.M."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Gurel P."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Shams A."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "de Los Reyes S.E."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Heidings J.B."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/author | "Moreland Z.G."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/pages | "eabl4733"xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/title | "Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia."xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/35857845 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35857845 |
| http://purl.uniprot.org/citations/35857845 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35857845 |
| http://purl.uniprot.org/uniprot/#_P24032-mappedCitation-35857845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35857845 |
| http://purl.uniprot.org/uniprot/#_Q9QZZ4-mappedCitation-35857845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35857845 |
| http://purl.uniprot.org/uniprot/#_P68139-mappedCitation-35857845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35857845 |
| http://purl.uniprot.org/uniprot/P24032 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35857845 |