| http://purl.uniprot.org/citations/35857850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35857850 | http://www.w3.org/2000/01/rdf-schema#comment | "Ryanodine receptor type 2 (RyR2) mutations have been linked to an inherited form of exercise-induced sudden cardiac death called catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT results from stress-induced sarcoplasmic reticular Ca2+ leak via the mutant RyR2 channels during diastole. We present atomic models of human wild-type (WT) RyR2 and the CPVT mutant RyR2-R2474S determined by cryo-electron microscopy with overall resolutions in the range of 2.6 to 3.6 Å, and reaching local resolutions of 2.25 Å, unprecedented for RyR2 channels. Under nonactivating conditions, the RyR2-R2474S channel is in a "primed" state between the closed and open states of WT RyR2, rendering it more sensitive to activation that results in stress-induced Ca2+ leak. The Rycal drug ARM210 binds to RyR2-R2474S, reverting the primed state toward the closed state. Together, these studies provide a mechanism for CPVT and for the therapeutic actions of ARM210."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.abo1272"xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Yuan Q."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Marks A.R."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Reiken S."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Melville Z."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Wronska A."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Miotto M.C."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Dridi H."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Sittenfeld L."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/author | "Weninger G."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/pages | "eabo1272"xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/title | "Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment."xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/35857850 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35857850 |
| http://purl.uniprot.org/citations/35857850 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35857850 |
| http://purl.uniprot.org/uniprot/#_P0DP23-mappedCitation-35857850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35857850 |
| http://purl.uniprot.org/uniprot/#_P68106-mappedCitation-35857850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35857850 |
| http://purl.uniprot.org/uniprot/#_Q92736-mappedCitation-35857850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35857850 |
| http://purl.uniprot.org/uniprot/P68106 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35857850 |
| http://purl.uniprot.org/uniprot/Q92736 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35857850 |