| http://purl.uniprot.org/citations/35858337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35858337 | http://www.w3.org/2000/01/rdf-schema#comment | "Hosts are continually selected to evolve new defenses against an ever-changing array of pathogens. To understand this process, we examined the genetic basis of resistance to the Drosophila A virus in Drosophila melanogaster. In a natural population, we identified a polymorphic transposable element (TE) insertion that was associated with an ∼19,000-fold reduction in viral titers, allowing flies to largely escape the harmful effects of infection by this virulent pathogen. The insertion occurs in the protein-coding sequence of the gene Veneno, which encodes a Tudor domain protein. By mutating Veneno with CRISPR-Cas9 in flies and expressing it in cultured cells, we show that the ancestral allele of the gene has no effect on viral replication. Instead, the TE insertion is a gain-of-function mutation that creates a gene encoding a novel resistance factor. Viral titers remained reduced when we deleted the TE sequence from the transcript, indicating that resistance results from the TE truncating the Veneno protein. This is a novel mechanism of virus resistance and a new way by which TEs can contribute to adaptation."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2122026119"xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Jiggins F.M."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Day J.P."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Olivieri F."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Cogni R."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Fabian D.K."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Tolosana I."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Akilli N."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Brosh O."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Merckx M."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/author | "Szkuta P."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/pages | "e2122026119"xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/title | "A novel transposable element-mediated mechanism causes antiviral resistance in Drosophila through truncating the Veneno protein."xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/35858337 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35858337 |
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| http://purl.uniprot.org/uniprot/#_M9PBB5-mappedCitation-35858337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35858337 |