| http://purl.uniprot.org/citations/35860266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35860266 | http://www.w3.org/2000/01/rdf-schema#comment | "GM-CSF-producing T helper (Th) cells play a crucial role in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). Recent studies have identified a distinct population of GM-CSF-producing Th cells, named ThGM cells, that also express cytokines TNF, IL-2, and IL-3, but lack expression of master transcription factors (TF) and signature cytokines of commonly recognized Th cell lineages. ThGM cells are highly encephalitogenic in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). Similar to Th17 cells, in response to IL-12, ThGM cells upregulate expression of T-bet and IFN-γ and switch their phenotype to Th1. Here we show that in addition to T-bet, TF RUNX3 also contributes to the Th1 switch of ThGM cells. T-bet-deficient ThGM cells in the CNS of mice with EAE had low expression of RUNX3, and knockdown of RUNX3 expression in ThGM cells abrogated the Th1-inducing effect of IL-12. Comparison of ThGM and Th1 cell transcriptomes showed that ThGM cells expressed a set of TFs known to inhibit the development of other Th lineages. Lack of expression of lineage-specific cytokines and TFs by ThGM cells, together with expression of TFs that inhibit the development of other Th lineages, suggests that ThGM cells are a non-polarized subset of Th cells with lineage characteristics."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2022.912583"xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/author | "Kumar G."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/author | "Xiao D."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/author | "Fortina P."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/author | "Zhang G.X."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/author | "Ciric B."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/author | "Rostami A."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/author | "Casella G."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/author | "Rasouli J."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/pages | "912583"xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/title | "Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype."xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/35860266 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35860266 |
| http://purl.uniprot.org/citations/35860266 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35860266 |
| http://purl.uniprot.org/uniprot/#_O88674-mappedCitation-35860266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35860266 |
| http://purl.uniprot.org/uniprot/#_Q8BPJ1-mappedCitation-35860266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35860266 |
| http://purl.uniprot.org/uniprot/#_Q3U1Q3-mappedCitation-35860266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35860266 |
| http://purl.uniprot.org/uniprot/#_Q921B7-mappedCitation-35860266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35860266 |
| http://purl.uniprot.org/uniprot/#_Q64131-mappedCitation-35860266 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35860266 |
| http://purl.uniprot.org/uniprot/Q64131 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35860266 |