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| http://purl.uniprot.org/citations/35879578 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca2+ is a universal second messenger that plays a wide variety of fundamental roles in cellular physiology. Thus, to warrant selective responses and to allow rapid mobilization upon specific stimuli, Ca2+ is accumulated in organelles to keep it at very low levels in the cytoplasm during resting conditions. Major Ca2+ storage organelles include the endoplasmic reticulum (ER), the mitochondria, and as recently demonstrated, the lysosome (Xu and Ren, Annu Rev Physiol 77:57-80, 2015). The importance of Ca2+ signaling deregulation in human physiology is underscored by its involvement in several human diseases, including lysosomal storage disorders, neurodegenerative disease and cancer (Shen et al., Nat Commun 3:731, 2012; Bae et al., J Neurosci 34:11485-11503, 2014). Recent evidence strongly suggests that lysosomal Ca2+ plays a major role in the regulation of lysosomal adaptation to nutrient availability through a lysosomal signaling pathway involving the lysosomal Ca2+ channel TRPML1 and the transcription factor TFEB, a master regulator for lysosomal function and autophagy (Sardiello et al., Science 325:473-477, 2009; Settembre et al., Science 332:1429-1433, 2011; Medina et al., Nat Cell Biol 17:288-299, 2015; Di Paola et al., Cell Calcium 69:112-121, 2018). Due to the tight relationship of this lysosomal Ca2+ channel and TFEB, in this chapter, we will focus on the role of the TRPML1/TFEB pathway in the regulation of lysosomal function and autophagy."xsd:string |
| http://purl.uniprot.org/citations/35879578 | http://purl.org/dc/terms/identifier | "doi:10.1007/164_2022_603"xsd:string |
| http://purl.uniprot.org/citations/35879578 | http://purl.uniprot.org/core/author | "Medina D.L."xsd:string |
| http://purl.uniprot.org/citations/35879578 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/35879578 | http://purl.uniprot.org/core/name | "Handb Exp Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/35879578 | http://purl.uniprot.org/core/pages | "109-126"xsd:string |
| http://purl.uniprot.org/citations/35879578 | http://purl.uniprot.org/core/title | "TRPML1 and TFEB, an Intimate Affair."xsd:string |
| http://purl.uniprot.org/citations/35879578 | http://purl.uniprot.org/core/volume | "278"xsd:string |
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