| http://purl.uniprot.org/citations/35895810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35895810 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of synaptic neurotransmitter receptor content is a fundamental mechanism for tuning synaptic efficacy during experience-dependent plasticity and behavioral adaptation. However, experimental approaches to track and modify receptor movements in integrated experimental systems are limited. Exploiting AMPA-type glutamate receptors (AMPARs) as a model, we generated a knock-in mouse expressing the biotin acceptor peptide (AP) tag on the GluA2 extracellular N-terminal. Cell-specific introduction of biotin ligase allows the use of monovalent or tetravalent avidin variants to respectively monitor or manipulate the surface mobility of endogenous AMPAR containing biotinylated AP-GluA2 in neuronal subsets. AMPAR immobilization precluded the expression of long-term potentiation and formation of contextual fear memory, allowing target-specific control of the expression of synaptic plasticity and animal behavior. The AP tag knock-in model offers unprecedented access to resolve and control the spatiotemporal dynamics of endogenous receptors, and opens new avenues to study the molecular mechanisms of synaptic plasticity and learning."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.abm5298"xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Hosy E."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Breillat C."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Choquet D."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Humeau Y."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Lampin-Saint-Amaux A."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Daburon S."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Nowacka A."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Sainlos M."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Fernandez-Monreal M."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Lanore F."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Getz A.M."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Francois U."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Zieger H.L."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/author | "Ducros M."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/pages | "eabm5298"xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/title | "High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning."xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/35895810 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35895810 |
| http://purl.uniprot.org/citations/35895810 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35895810 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW90-mappedCitation-35895810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35895810 |