| http://purl.uniprot.org/citations/35908044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35908044 | http://www.w3.org/2000/01/rdf-schema#comment | "Innate lymphoid cells (ILC) promote lung inflammation in asthma through cytokine production. RNA-binding proteins (RBPs) are critical post-transcriptional regulators, although less is known about RBPs in ILC biology. Here, we demonstrate that RNA-binding motif 3 (RBM3) is highly expressed in lung ILCs and is further induced by alarmins TSLP and IL-33. Rbm3-/- and Rbm3-/-Rag2-/- mice exposed to asthma-associated Alternaria allergen develop enhanced eosinophilic lung inflammation and ILC activation. IL-33 stimulation studies in vivo and in vitro show that RBM3 suppressed lung ILC responses. Further, Rbm3-/- ILCs from bone marrow chimeric mice display increased ILC cytokine production suggesting an ILC-intrinsic suppressive function of RBM3. RNA-sequencing of Rbm3-/- lung ILCs demonstrates increased expression of type 2/17 cytokines and cysteinyl leukotriene 1 receptor (CysLT1R). Finally, Rbm3-/-Cyslt1r-/- mice show dependence on CysLT1R for accumulation of ST2+IL-17+ ILCs. Thus, RBM3 intrinsically regulates lung ILCs during allergen-induced type 2 inflammation that is partially dependent on CysLT1R."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-32176-5"xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Seumois G."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Pilotte J."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Vanderklish P.W."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Mondal M."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Badrani J.H."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Leng A."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Doherty T.A."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Khorram N."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "McGee H.M."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Lund S.J."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Cavagnero K."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Baum R.E."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Naji L.H."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Strohm A.N."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Amadeo M."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Civello B."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Haung Y.A."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/author | "Lacasa L."xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/35908044 | http://purl.uniprot.org/core/pages | "4435"xsd:string |