| http://purl.uniprot.org/citations/35921527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35921527 | http://www.w3.org/2000/01/rdf-schema#comment | "Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells with TET2 mutations promotes the development of T follicular helper (TFH)-like tumor cells. Here, we investigated the mechanism by which TET2-mutant immune cells enable AITL development using mouse models and human samples. Among the 2 mouse models, mice lacking Tet2 in all the blood cells (Mx-Cre × Tet2flox/flox × G17V RHOA transgenic mice) spontaneously developed AITL for approximately up to a year, while mice lacking Tet2 only in the T cells (Cd4-Cre × Tet2flox/flox × G17V RHOA transgenic mice) did not. Therefore, Tet2-deficient immune cells function as a niche for AITL development. Single-cell RNA-sequencing (scRNA-seq) of >50 000 cells from mouse and human AITL samples revealed significant expansion of aberrant B cells, exhibiting properties of activating light zone (LZ)-like and proliferative dark zone (DZ)-like germinal center B (GCB) cells. The GCB cells in AITL clonally evolved with recurrent mutations in genes related to core histones. In silico network analysis using scRNA-seq data identified Cd40-Cd40lg as a possible mediator of GCB and tumor cell cluster interactions. Treatment of AITL model mice with anti-Cd40lg inhibitory antibody prolonged survival. The genes expressed in aberrantly expanded GCB cells in murine tumors were also broadly expressed in the B-lineage cells of TET2-mutant human AITL. Therefore, ACH-derived GCB cells could undergo independent clonal evolution and support the tumorigenesis in AITL via the CD40-CD40LG axis."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.2022015451"xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Chiba S."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Abe Y."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Ito T."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Narita K."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Nakamura N."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Takahashi S."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Suzuki A."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Mizuno S."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Fujisawa M."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Suma S."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Ishikawa S."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Miura F."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Fukumoto K."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Nguyen T.B."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Kaneko C."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Usuki K."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Makishima K."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Matsue K."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Sakata-Yanagimoto M."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Suehara Y."xsd:string |
| http://purl.uniprot.org/citations/35921527 | http://purl.uniprot.org/core/author | "Nguyen Y.T.M."xsd:string |