| http://purl.uniprot.org/citations/35922005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35922005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35922005 | http://www.w3.org/2000/01/rdf-schema#comment | "Highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus 2 (refs. 1,2) (SARS-CoV-2), Middle East respiratory syndrome coronavirus3 (MERS-CoV) and SARS-CoV-1 (ref. 4), vary in their transmissibility and pathogenicity. However, infection by all three viruses results in substantial apoptosis in cell culture5-7 and in patient tissues8-10, suggesting a potential link between apoptosis and pathogenesis of coronaviruses. Here we show that caspase-6, a cysteine-aspartic protease of the apoptosis cascade, serves as an important host factor for efficient coronavirus replication. We demonstrate that caspase-6 cleaves coronavirus nucleocapsid proteins, generating fragments that serve as interferon antagonists, thus facilitating virus replication. Inhibition of caspase-6 substantially attenuates lung pathology and body weight loss in golden Syrian hamsters infected with SARS-CoV-2 and improves the survival of mice expressing human DPP4 that are infected with mouse-adapted MERS-CoV. Our study reveals how coronaviruses exploit a component of the host apoptosis cascade to facilitate virus replication."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-022-05148-4"xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-022-05148-4"xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Hou Y."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Hou Y."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Hu B."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Hu B."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Lee K.S."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Lee K.S."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Jin D.Y."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Jin D.Y."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Luo C."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Luo C."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/35922005 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |